Pharmacodynamics of bisphosphonates in arthritis

Oral bisphosphonates-associated osteonecrosis in rheumatoid arthritis.

Adverse effects associated with the use of bisphosphonates are infrequent and consist of pyrexia, renal function impairment, and hypocalcemia. Bisphosphonates-associated osteonecrosis of the jaws is an uncommon but potentially serious complication of intravenous bisphosphonate therapy in cancer patients. The degree of risk for osteonecrosis in patients taking oral bisphosphonates, such as alend...

BISPHOSPHONATES IN THE TREATMENT OF RHEUMATOID ARTHRITIS With special reference to collagen degradation

Direct Bone Destruction by Neutrophils in Collageninduced Arthritis Treated with Bisphosphonates

To identify the direct destruction of bone by neutrophils in collagen­induced arthritis treated with powerful anti­osteoclastic bone resorptive agents, bisphosphonates, we designed the experiments to examine whether the bone destruction induced by collagen­induced arthritis (CIA) was inhibited by nitrogen­containing bisphosphonates (NBPs) or not, and examined histologically and ultrastructually...

Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy.

  Methotrexate (MTX) is a derivative of folic acid (folate) and commonly used as an anchor drug for the treatment of rheumatoid arthritis (RA). The pharmacokinetics (PK) and pharmacodynamics (PD) of MTX entirely depends on the function of specific transporters that belong to the two major superfamilies, solute carrier transporters and ATP-binding cassette transporters. Several transporters have...

Practice of oral and maxillofacial surgeons in bisphosphonates users in Tehran: brief report

Background: Although the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is very difficult, it can be prevented. The aim of this study was to investigate the knowledge and practice of oral and maxillofacial surgeons in the treatment of bisphosphonates user patients. Methods: This was a cross-sectional study carried out by census sampling of oral and maxillofacial surgeons ...